SETD7 anticorps (AA 107-366)

N° du produit ABIN7193392

Cet anticorps Souris Monoclonal détecte spécifiquement SETD7 dans WB, ELISA et FACS. Il présente une réactivité avec des échantillons de Humain, Rat et Singe.

Aperçu rapide pour SETD7 anticorps (AA 107-366) (ABIN7193392)

Antigène: SETD7 (SET Domain Containing (Lysine Methyltransferase) 7 (SETD7))

Reactivité: Humain, Rat, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SETD7 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Clone: 1B3B8

Détail du produit anti-SETD7 anticorps

Épitope: AA 107-366

Fonction: SETD7 Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human SETD7 (AA: 107-366) expressed in E. Coli.

Isotype: IgG2a

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Détails sur SETD7

Antigène: SETD7 (SET Domain Containing (Lysine Methyltransferase) 7 (SETD7))

Autre désignation: SETD7

Sujet:

Histone methyltransferase that specifically monomethylates Lys-4 of histone H3. H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates Lys-189 of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates Lys-372 of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.

Poids moléculaire: 40.7 kDa

UniProt: Q8WTS6