MAVS anticorps (N-Term)

N° du produit ABIN2783802

Cet anticorps Lapin Polyclonal détecte spécifiquement MAVS dans WB et IHC. Il présente une réactivité envers Humain, Souris et Boeuf (Vache).

Aperçu rapide pour MAVS anticorps (N-Term) (ABIN2783802)

Antigène: MAVS (Mitochondrial Antiviral Signaling Protein (MAVS))

Reactivité: Humain, Souris, Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAVS est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-MAVS anticorps

Épitope: N-Term

Séquence: ETQAPESPGE NSEQALQTLS PRAIPRNPDG GPLESSSDLA ALSPLTSSGH

Homologie: Cow: 79%, Human: 100%, Mouse: 79%

Attributs du produit: This is a rabbit polyclonal antibody against VISA. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human VISA

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 896 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur MAVS

Antigène: MAVS (Mitochondrial Antiviral Signaling Protein (MAVS))

Autre désignation: VISA

Sujet: Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 or by the cytoplasmic RNA helicases MDA5 and RIGI (ROBO3). These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK) and IKKB (IKBKB), which activate NFKB, or TBK1 and IKKE (IKBKE), which activate IRF3. Activated IRF3 and NFKB induce transcription of IFNB (IFNB1). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1). For RIGI, the intermediary protein is mitochondria-bound VISA. Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 (MIM 603029) or by the cytoplasmic RNA helicases MDA5 (MIM 606951) and RIGI (ROBO3, MIM 608630). These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK, MIM 600664) and IKKB (IKBKB, MIM 603258), which activate NFKB (see MIM 164011), or TBK1 (MIM 604834) and IKKE (IKBKE, MIM 605048), which activate IRF3 (MIM 603734). Activated IRF3 and NFKB induce transcription of IFNB (IFNB1, MIM 147640). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1, MIM 607601). For RIGI, the intermediary protein is mitochondria-bound IPS1 (Sen and Sarkar, 2005 [PubMed 16239922]).[supplied by OMIM]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CARDIF, DKFZp666M015, FLJ27482, FLJ41962, IPS-1, KIAA1271, MAVS, IPS1, VISA
Protein Interaction Partner: MIB2, KCNIP3, DDX58, UBC, TRAF6, TRAF3, UBXN1, TMEM173, SMURF2, HCVgp1, AMFR, MFN1, MFN2, MUL1, TOMM70A, FLOT2, NDFIP1, SMURF1, TBK1, IKBKG, TICAM1, TRAF2, MAP3K7, SRC, IRF7, IRF3, IKBKE, TSPAN6, RARRES3, ECSIT, PCBP2, ITCH, IFIH1, PSMA7, WDR5, HECTD3, PD
Protein Size: 896

Poids moléculaire: 56 kDa

ID gène: 57506

NCBI Accession: NM_020746, NP_065797

UniProt: Q2HWT5

Pathways: Activation of Innate immune Response, Inositol Metabolic Process, Hepatitis C