Cortactin anticorps (N-Term)

N° du produit ABIN2784757

Cet anticorps Lapin Polyclonal détecte spécifiquement Cortactin dans WB et IHC. Il présente une réactivité envers Humain, Souris, Rat, Chien, Boeuf (Vache), Cobaye, Cheval, Lapin et Poisson zèbre (Danio rerio).

Aperçu rapide pour Cortactin anticorps (N-Term) (ABIN2784757)

Antigène: Cortactin (CTTN)

Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Cobaye, Cheval, Lapin, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cortactin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Cortactin anticorps

Épitope: N-Term

Séquence: KHCSQVDSVR GFGGKFGVQM DRVDQSAVGF EYQGKTEKHA SQKDYSSGFG

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against CTTN. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human CTTN

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 550 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Cortactin

Antigène: Cortactin (CTTN)

Autre désignation: CTTN

Sujet: CTTN is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. CTTN is localized in the cytoplasm and in areas of the cell-substratum contacts. It has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, CTTN is degraded in a caspase-dependent manner. The aberrant regulation of t CTTN contributes to tumor cell invasion and metastasis.This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Two splice variants that encode different isoforms have been identified for this gene.
Alias Symbols: EMS1, FLJ34459
Protein Interaction Partner: SPRR2A, CDC37, CTTN, UBC, NEDD8, RPA3, RPA2, RPA1, VTA1, GSPT2, ATG7, UGDH, ME1, IDE, GSPT1, GARS, CTNNA1, ATP6V1C1, APEH, STAT1, SSB, SNX2, SNX1, SHMT2, SHMT1, SARS, RDX, ACTR2, NPM1, LMNA, ACTG1, ACTR3, PAN2, ATF2, DNM2, NCF1, Mbp, ASAP1, CORO1B, SDHAF2
Protein Size: 550

Poids moléculaire: 61 kDa

ID gène: 2017

NCBI Accession: NM_005231, NP_005222

UniProt: Q8N707

Pathways: Signalisation MAPK