COPS8 anticorps (Middle Region)

N° du produit ABIN2784840

Détail du produit anti-COPS8 anticorps

Antigène: COPS8 (COP9 Signalosome Subunit 8 (COPS8))

Épitope: Middle Region

Reactivité: Humain, Rat, Souris, Boeuf (Vache), Cobaye, Cheval, Lapin, Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp COPS8 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: TRMVLPRKPV AGALDVSFNK FIPLSEPAPV PPIPNEQQLA RLTDYVAFLE

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against COPS8. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human COPS8

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 209 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-COPS8 (ABIN2784840)

Pick, Golan, Zimbler, Guo, Sharaby, Tsuge, Hofmann, Wei: "The minimal deneddylase core of the COP9 signalosome excludes the Csn6 MPN- domain." dans: PLoS ONE, Vol. 7, Issue 8, pp. e43980, (2012) (PubMed).

Détails sur COPS8

Antigène: COPS8 (COP9 Signalosome Subunit 8 (COPS8))

Autre désignation: COPS8 (COPS8 Produits)

Synonymes: anticorps COP9, anticorps CSN8, anticorps SGN8, anticorps csn8, anticorps cops8, anticorps MGC76051, anticorps MGC80215, anticorps DDBDRAFT_0167123, anticorps DDBDRAFT_0233107, anticorps DDB_0167123, anticorps DDB_0233107, anticorps zgc:56319, anticorps zgc:86840, anticorps MGC86182, anticorps 9430009J09Rik, anticorps AA408242, anticorps Csn8, anticorps Sgn8, anticorps CONSTITUTIVE PHOTOMORPHOGENIC 9, anticorps COP9 SIGNALOSOME SUBUNIT 8, anticorps DL3095C, anticorps EMB143, anticorps EMBRYO DEFECTIVE 143, anticorps FCAALL.131, anticorps FUS7, anticorps FUSCA 7, anticorps FUSCA PROTEIN FUS7, anticorps CG13383, anticorps CG33297, anticorps CG42522, anticorps CH8, anticorps Dch8, anticorps Dmel\\CG42522, anticorps Dmel_CG13383, anticorps l(2)SH1829, anticorps l(2)SH2 1829, anticorps COP9 signalosome subunit 8, anticorps COP9 signalosome subunit 8 S homeolog, anticorps COP9 signalosome complex subunit 8, anticorps COP9 signalosome subunit 8 L homeolog, anticorps COP9 signalosome, subunit CSN8, anticorps COPS8, anticorps Cops8, anticorps cops8, anticorps cops8.S, anticorps CSN8, anticorps csn8, anticorps cops8.L, anticorps COP9

Sujet: The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Alias Symbols: COP9, CSN8, MGC1297, MGC43256, SGN8
Protein Interaction Partner: USHBP1, GPS1, cul1, WDR77, SRRT, COPS7A, VIM, COPS4, FBXO6, FBXW4, COPS5, vpr, IRF5, DDIT3, COPS2, COPS3, COPS6, PINK1, RFWD2, CUL4A, UBC, LRR1, DDA1, DDB2, DCUN1D1, VPRBP, CUL2, CUL3, CUL4B, CUL5, NEDD8, JUN, GFER, ERCC8, DDB1, CTNNB1, RAE1, COPS8, EIF3E
Protein Size: 209

Poids moléculaire: 23 kDa

ID gène: 10920

NCBI Accession: NM_006710, NP_006701

UniProt: Q99627

Pathways: Cycle Cellulaire