CISH anticorps (N-Term)

N° du produit ABIN2785100

L’anticorps Lapin Polyclonal anti-CISH a été validé pour WB. Il convient pour détecter CISH dans des échantillons de Humain, Souris, Rat, Porc, Boeuf (Vache), Cheval, Lapin et Chien.

Aperçu rapide pour CISH anticorps (N-Term) (ABIN2785100)

Antigène: CISH (Cytokine Inducible SH2-Containing Protein (CISH))

Reactivité: Humain, Souris, Rat, Porc, Boeuf (Vache), Cheval, Lapin, Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CISH est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-CISH anticorps

Épitope: N-Term

Séquence: RESGWYWGSI TASEARQHLQ KMPEGTFLVR DSTHPSYLFT LSVKTTRGPT

Homologie: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against Cish. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide corresponding to a region of Mouse

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 257 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur CISH

Antigène: CISH (Cytokine Inducible SH2-Containing Protein (CISH))

Autre désignation: Cish

Sujet: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Alias Symbols: AI385595, CIS1, Cis, F17, F23
Protein Interaction Partner: GHR, Socs2, Lepr, Epor, Prkcq, Prkcb, Prkca, Ubc, Abl1, Cul5, TCEB2, TCEB1, Stat5a,
Protein Size: 257

Poids moléculaire: 28 kDa

ID gène: 12700

NCBI Accession: NM_009895, NP_034025

UniProt: Q62225

Pathways: Signalistation JAK/STAT, Response to Growth Hormone Stimulus