SOCS7 anticorps (N-Term)

N° du produit ABIN2785525

L’anticorps anti-SOCS7 Polyclonal Lapin est utilisé pour la détection de SOCS7 dans des échantillons de Humain, Souris, Rat, Boeuf (Vache), Lapin, Porc, Cheval, Chien et Cobaye. Il a été validé pour WB.

Aperçu rapide pour SOCS7 anticorps (N-Term) (ABIN2785525)

Antigène: SOCS7 (Suppressor of Cytokine Signaling 7 (SOCS7))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Lapin, Porc, Cheval, Chien, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SOCS7 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-SOCS7 anticorps

Épitope: N-Term

Séquence: GSAGRELDAG RKPKLTRTQS AFSPVSFSPL FTGETVSLVD VDISQRGLTS

Homologie: Cow: 100%, Dog: 92%, Guinea Pig: 83%, Horse: 100%, Human: 100%, Mouse: 85%, Pig: 92%, Rabbit: 100%, Rat: 92%

Attributs du produit: This is a rabbit polyclonal antibody against SOCS7. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N-terminal region of Human SOCS7

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeat freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur SOCS7

Antigène: SOCS7 (Suppressor of Cytokine Signaling 7 (SOCS7))

Autre désignation: SOCS7

Sujet: SOCS7 regulates signaling cascades probably through protein ubiquitination and/or sequestration. It functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. It inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. SOCS7 may be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Protein Interaction Partner: SEPT6, SORBS3, STAT5A, STAT3, CUL5, IRS4, PIK3R2, TUBB4B, TUBA1A, IRS2, NCK1, PLCG1, PIK3R1, EGFR, GRB2,
Protein Size: 331

Poids moléculaire: 36 kDa

ID gène: 30837