PIAS2 anticorps (N-Term)

N° du produit ABIN2785610

L’anticorps Lapin Polyclonal anti-PIAS2 a été validé pour WB. Il convient pour détecter PIAS2 dans des échantillons de Humain, Souris, Rat, Chien, Boeuf (Vache), Cheval, Lapin, Cobaye et Porc.

Aperçu rapide pour PIAS2 anticorps (N-Term) (ABIN2785610)

Antigène: PIAS2 (Protein Inhibitor of Activated STAT, 2 (PIAS2))

Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Cheval, Lapin, Cobaye, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PIAS2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-PIAS2 anticorps

Épitope: N-Term

Séquence: RELYRRRYPR TLEGLSDLST IKSSVFSLDG GSSPVEPDLA VAGIHSLPST

Homologie: Cow: 93%, Dog: 92%, Guinea Pig: 92%, Horse: 92%, Human: 100%, Mouse: 92%, Pig: 93%, Rabbit: 92%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against PIAS2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human PIAS2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 572 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur PIAS2

Antigène: PIAS2 (Protein Inhibitor of Activated STAT, 2 (PIAS2))

Autre désignation: PIAS2

Sujet: Pias2 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. It plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. It seems to be mostly involved in gene silencing. It binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. This gene encodes a protein involved in the regulation of transcription factors involved in MAP kinase signaling. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. Two alternatively spliced transcripts encoding different isoforms have been described.
Alias Symbols: MGC102682, MIZ1, PIASX-ALPHA, PIASX-BETA, SIZ2, ZMIZ4, miz, DIP, MIZ, ARIP3, PIASX
Protein Interaction Partner: HIC1, GOLGA2, GFAP, PHC1, TRIM23, ZBTB8A, SUMO1P1, ACY3, TSR2, NAV2, CCHCR1, CCNDBP1, MAPKAPK2, ZBED1, PIAS2, SUMO1, UBE2I, TP53, PRKAB2, MX2, TRIM63, TRIM55, CTBP1, GTF2I, SUMO2, SUMO3, MYC, DNMT3A, TICAM2, RUFY1, PIAS4, C1QA, ADA, PAXIP1, UBC, PLAGL1, P
Protein Size: 572

Poids moléculaire: 63 kDa

ID gène: 9063

NCBI Accession: NM_173206, NP_775298

Pathways: Signalistation JAK/STAT, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling