VPS4A anticorps (N-Term)

N° du produit ABIN2785950

Détail du produit anti-VPS4A anticorps

Antigène: VPS4A (Vacuolar Protein Sorting-Associated Protein 4A (VPS4A))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Lapin, Boeuf (Vache), Chien, Cheval, Cobaye, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VPS4A est non-conjugé

Application: Western Blotting (WB)

Séquence: YFLHAIKYEA HSDKAKESIR AKCVQYLDRA EKLKDYLRSK EKHGKKPVKE

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against VPS4A. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human VPS4A

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 437 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-VPS4A (ABIN2785950)

Taylor, Hanson, Kielian: "Ubiquitin depletion and dominant-negative VPS4 inhibit rhabdovirus budding without affecting alphavirus budding." dans: Journal of virology, Vol. 81, Issue 24, pp. 13631-9, (2007) (PubMed).

Détails sur VPS4A

Antigène: VPS4A (Vacuolar Protein Sorting-Associated Protein 4A (VPS4A))

Autre désignation: VPS4A (VPS4A Produits)

Synonymes: anticorps vsp4, anticorps SKD1, anticorps SKD1A, anticorps SKD2, anticorps VPS4, anticorps VPS4-1, anticorps zgc:153907, anticorps 4930589C15Rik, anticorps AI325971, anticorps AW553189, anticorps vacuolar protein sorting 4 homolog A, anticorps vacuolar sorting protein 4, anticorps vacuolar protein sorting 4 homolog A L homeolog, anticorps vacuolar protein sorting 4a homolog A (S. cerevisiae), anticorps vacuolar protein sorting 4A, anticorps VPS4A, anticorps TP03_0351, anticorps vps4a, anticorps vps4a.L, anticorps Vps4a

Sujet: VPS4A is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast.The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really an yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16, the gene for the other resides on chromosome 18. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: FLJ22197, SKD1, SKD2, VPS4, VPS4-1, SKD1A
Protein Interaction Partner: FBXO6, UBC, CFTR, KCND3, CHMP4B, CHMP1B, CHMP4A, CHMP2A, VPS4A, CHMP1A, CHMP4C, gag, VTA1, CHMP3, CHMP5, HGS, NPC1, BABAM1, VPS4B, RND2,
Protein Size: 437

Poids moléculaire: 49 kDa

ID gène: 27183

NCBI Accession: NM_013245, NP_037377

UniProt: Q9UN37

Pathways: Dynamique des Microtubules, CXCR4-mediated Signaling Events