DKK2 anticorps (Middle Region)

N° du produit ABIN2786024

Cet anticorps Lapin Polyclonal détecte spécifiquement DKK2 dans WB. Il présente une réactivité envers Humain, Souris, Rat, Chien, Boeuf (Vache), Cobaye, Cheval et Lapin.

Aperçu rapide pour DKK2 anticorps (Middle Region) (ABIN2786024)

Antigène: DKK2 (Dickkopf 2 Homolog (DKK2))

Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Cobaye, Cheval, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DKK2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-DKK2 anticorps

Épitope: Middle Region

Séquence: NGICIPVTES ILTPHIPALD GTRHRDRNHG HYSNHDLGWQ NLGRPHSKMP

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against Dkk2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide corresponding to a region of Mouse

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 259 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur DKK2

Antigène: DKK2 (Dickkopf 2 Homolog (DKK2))

Autre désignation: Dkk2

Sujet: Dkk2 antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer's disease.
Alias Symbols: -
Protein Size: 259

Poids moléculaire: 28 kDa

ID gène: 56811

NCBI Accession: NM_020265, NP_064661

UniProt: Q9QYZ8

Pathways: Signalisation WNT