PMS2 anticorps (Middle Region)

N° du produit ABIN2786522

Cet anticorps anti-PMS2 est un anticorps Lapin Polyclonal détectant PMS2 dans WB. Adapté pour Humain, Rat, Lapin, Boeuf (Vache), Cobaye, Chien, Cheval et Saccharomyces cerevisiae.

Aperçu rapide pour PMS2 anticorps (Middle Region) (ABIN2786522)

Antigène: PMS2 (PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2))

Reactivité: Humain, Rat, Lapin, Boeuf (Vache), Cobaye, Chien, Cheval, Saccharomyces cerevisiae

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PMS2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-PMS2 anticorps

Épitope: Middle Region

Séquence: INKKVVPLDF SMSSLAKRIK QLHHEAQQSE GEQNYRKFRA KICPGENQAA

Homologie: Cow: 85%, Dog: 92%, Guinea Pig: 100%, Horse: 92%, Human: 100%, Rabbit: 92%, Rat: 92%, Yeast: 91%

Attributs du produit: This is a rabbit polyclonal antibody against PMS2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human PMS2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 862 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur PMS2

Antigène: PMS2 (PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2))

Autre désignation: PMS2

Sujet: PMS2 is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors.This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene.
Alias Symbols: HNPCC4, PMS2CL, PMSL2
Protein Interaction Partner: UBC, MLH1, PCNA, PMS2P1, NSF, MSH2, LMNA, MSH6, SPRTN, BRIP1, FAN1, CLSPN, TOPBP1, PSD2, MMS19, ATAD3A, NSUN2, UBR5, COPG2, PSD3, COPG1, RUVBL2, EXO1, AIFM1, RUVBL1, XPO1, SMARCA4, RFC2, PSMD5, PSMC6, PSMC3, PSMC2, PSMC1, PRKDC, PPP2CA, PIK3C2A, MSH3, MCM
Protein Size: 862

Poids moléculaire: 96 kDa

ID gène: 5395

NCBI Accession: NM_000535, NP_000526

UniProt: P54278

Pathways: Réparation de l'ADN, Production of Molecular Mediator of Immune Response