TDP1 anticorps (Middle Region)

N° du produit ABIN2787112

Cet anticorps anti-TDP1 Polyclonal Lapin (ABIN2787112) détecte spécifiquement TDP1 dans WB. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Cheval, Boeuf (Vache), Cobaye, Chien et Lapin.

Aperçu rapide pour TDP1 anticorps (Middle Region) (ABIN2787112)

Antigène: TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))

Reactivité: Humain, Souris, Rat, Cheval, Boeuf (Vache), Cobaye, Chien, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TDP1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-TDP1 anticorps

Épitope: Middle Region

Fonction: Tdp1 Antibody - middle region

Séquence: ETNVYLIGST PGRFQGSHRD NWGHFRLRKL LQAHAPSTPK GECWPIVGQF

Homologie: Cow: 92%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 86%, Rabbit: 93%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against Tdp1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide corresponding to a region of Mouse

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP57199-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur TDP1

Antigène: TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))

Autre désignation: Tdp1

Sujet:

Background Information: Tdp1 is a DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. It catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. It hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. It acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. It has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. It has no exonuclease activity towards DNA or RNA with a 3'phosphate.

Gene Name: Tyrosyl-DNA phosphodiesterase 1

Alternative Symbols: SC, SCAN1, Gm40556, MLZ-501, AI838772, AW493413, 2810481F14Rik, 4921509N21Rik, E430034L06Rik

Poids moléculaire: 64kDa

ID gène: 104884

NCBI Accession: NP_082630

UniProt: Q8BJ37