Calreticulin anticorps (Middle Region)

N° du produit ABIN2787864

Cet anticorps Lapin Polyclonal détecte spécifiquement Calreticulin dans WB et IHC. Il présente une réactivité avec des échantillons de Humain, Rat, Souris, Chien, Cobaye, Boeuf (Vache), Lapin, Cheval et Poisson zèbre (Danio rerio).

Aperçu rapide pour Calreticulin anticorps (Middle Region) (ABIN2787864)

Antigène: Calreticulin (CALR)

Reactivité: Humain, Rat, Souris, Chien, Cobaye, Boeuf (Vache), Lapin, Cheval, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Calreticulin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Calreticulin anticorps

Épitope: Middle Region

Fonction: CALR Antibody - middle region

Séquence: ASKPEDWDER AKIDDPTDSK PEDWDKPEHI PDPDAKKPED WDEEMDGEWE

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Attributs du produit: This is a rabbit polyclonal antibody against CALR. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human CALR

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP58880-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur Calreticulin

Antigène: Calreticulin (CALR)

Autre désignation: CALR

Sujet:

Background Information: Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium.

Gene Name: Calreticulin

Alternative Symbols: RO, CRT, SSA, cC1qR, HEL-S-99n

Protein Name: Calreticulin

Poids moléculaire: 46kDa

ID gène: 811

NCBI Accession: NP_004334

UniProt: P27797

Pathways: Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, ER-Nucleus Signaling, Unfolded Protein Response