Caspase 1 anticorps (Middle Region)

N° du produit ABIN2787901

L’anticorps Lapin Polyclonal anti-Caspase 1 a été validé pour WB. Il convient pour détecter Caspase 1 dans des échantillons de Humain, Cheval, Lapin et Saccharomyces cerevisiae.

Aperçu rapide pour Caspase 1 anticorps (Middle Region) (ABIN2787901)

Antigène: Caspase 1 (CASP1)

Reactivité: Humain, Cheval, Lapin, Saccharomyces cerevisiae

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Caspase 1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Caspase 1 anticorps

Épitope: Middle Region

Séquence: LQTRVLNKEE MEKVKRENAT VMDKTRALID SVIPKGAQAC QICITYICEE

Homologie: Horse: 79%, Human: 100%, Rabbit: 79%, Yeast: 100%

Attributs du produit: This is a rabbit polyclonal antibody against CASP1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human CASP1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 383 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Caspase 1

Antigène: Caspase 1 (CASP1)

Autre désignation: CASP1

Sujet: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms.
Alias Symbols: ICE, IL1BC, P45
Protein Interaction Partner: ced-3, ced-4, VAC14, BCL2L1, UBC, XK, PLA2G4B, IL33, IL1B, PARP1, BIRC3, TRAF2, CEBPB, TIRAP, CARD17, CARD16, CARD8, PLA2G4A, CDK11B, NLRP1, ATN1, ATXN3, PYCARD, NLRC4, NOD1, CASP14, RIPK2, PAK1, PARK2, NEDD4, BID, IL18, PSEN2, NFE2L2, AR, BCAP31, MAPT, L
Protein Size: 383

Poids moléculaire: 10 kDa

ID gène: 834

NCBI Accession: NM_001223, NP_001214

UniProt: P29466

Pathways: Apoptose, Interferon-gamma Pathway, Positive Regulation of Endopeptidase Activity, Inflammasome