Caspase 1 anticorps (Middle Region)
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- Antigène Voir toutes Caspase 1 (CASP1) Anticorps
- Caspase 1 (CASP1)
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Épitope
- Middle Region
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Reactivité
- Humain, Cheval, Lapin, Saccharomyces cerevisiae
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp Caspase 1 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- LQTRVLNKEE MEKVKRENAT VMDKTRALID SVIPKGAQAC QICITYICEE
- Homologie
- Horse: 79%, Human: 100%, Rabbit: 79%, Yeast: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against CASP1. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the middle region of human CASP1
- Top Product
- Discover our top product CASP1 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 383 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- Caspase 1 (CASP1)
- Autre désignation
- CASP1 (CASP1 Produits)
- Synonymes
- anticorps ICE, anticorps IL1BC, anticorps P45, anticorps Il1bc, anticorps Ice, anticorps CASP1, anticorps CG5370, anticorps DCP-1, anticorps DCP1, anticorps Dcp1, anticorps Dmel\\CG5370, anticorps ccp1, anticorps dcp-1, anticorps dcp1, anticorps l(2)01862, anticorps l(2)02132, anticorps caspase 1, anticorps caspase 1, apoptosis-related cysteine peptidase, anticorps caspase 4, apoptosis-related cysteine peptidase, anticorps Death caspase-1, anticorps caspase-1, anticorps caspase, anticorps caspase recruitment domain-containing protein 16, anticorps caspase 4, anticorps CASP1, anticorps Casp1, anticorps CASP4, anticorps Dcp-1, anticorps Caspase1, anticorps LOC5564196, anticorps LOC451519
- Sujet
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This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms.
Alias Symbols: ICE, IL1BC, P45
Protein Interaction Partner: ced-3, ced-4, VAC14, BCL2L1, UBC, XK, PLA2G4B, IL33, IL1B, PARP1, BIRC3, TRAF2, CEBPB, TIRAP, CARD17, CARD16, CARD8, PLA2G4A, CDK11B, NLRP1, ATN1, ATXN3, PYCARD, NLRC4, NOD1, CASP14, RIPK2, PAK1, PARK2, NEDD4, BID, IL18, PSEN2, NFE2L2, AR, BCAP31, MAPT, L
Protein Size: 383 - Poids moléculaire
- 10 kDa
- ID gène
- 834
- NCBI Accession
- NM_001223, NP_001214
- UniProt
- P29466
- Pathways
- Apoptose, Interferon-gamma Pathway, Positive Regulation of Endopeptidase Activity, Inflammasome
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