CD8 alpha anticorps (Middle Region)

N° du produit ABIN2787942

Cet anticorps anti-CD8 alpha Polyclonal Lapin (ABIN2787942) détecte spécifiquement CD8 alpha dans WB. L’anticorps est réactif avec des échantillons de Humain et Chien.

Aperçu rapide pour CD8 alpha anticorps (Middle Region) (ABIN2787942)

Antigène: CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Reactivité: Humain, Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CD8 alpha est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-CD8 alpha anticorps

Épitope: Middle Region

Fonction: CD8A Antibody - middle region

Séquence: GKRLGDTFVL TLSDFRRENE GYYFCSALSN SIMYFSHFVP VFLPAKPTTT

Homologie: Dog: 79%, Human: 100%

Attributs du produit: This is a rabbit polyclonal antibody against CD8A. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human CD8A

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP59114-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur CD8 alpha

Antigène: CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Autre désignation: CD8A

Sujet:

Background Information: The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a corepressor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains, or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain isoforms. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name: CD8a molecule

Alternative Symbols: CD8, p32, Leu2

Protein Name: T-cell surface glycoprotein CD8 alpha chain

Poids moléculaire: 26 kDa

ID gène: 925

NCBI Accession: NP_001139345

UniProt: P01732

Pathways: TCR Signaling