FAS anticorps (N-Term)

N° du produit ABIN2787943

Cet anticorps anti-FAS Polyclonal Lapin (ABIN2787943) détecte spécifiquement FAS dans WB. L’anticorps est réactif avec des échantillons de Humain, Porc et Chévre.

Aperçu rapide pour FAS anticorps (N-Term) (ABIN2787943)

Antigène: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Reactivité: Humain, Porc, Chévre

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FAS est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-FAS anticorps

Épitope: N-Term

Fonction: FAS Antibody - N-terminal region

Séquence: GLHHDGQFCH KPCPPGERKA RDCTVNGDEP DCVPCQEGKE YTDKAHFSSK

Homologie: Goat: 100%, Human: 100%, Pig: 93%

Attributs du produit: This is a rabbit polyclonal antibody against FAS. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human FAS

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP59115-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur FAS

Antigène: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Autre désignation: FAS

Sujet:

Background Information: FAS is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.

Gene Name: Fas (TNF receptor superfamily, member 6)

Alternative Symbols: APT1, CD95, FAS1, APO-1, FASTM, ALPS1A, TNFRSF6

Protein Name: Tumor necrosis factor receptor superfamily member 6

Poids moléculaire: 36kDa

ID gène: 355

NCBI Accession: NP_000034

UniProt: P25445

Pathways: Signalisation p53, Apoptose, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity