PEN2 anticorps (C-Term)

N° du produit ABIN2788066

Cet anticorps anti-PEN2 est un anticorps Lapin Polyclonal détectant PEN2 dans WB. Adapté pour Humain, Souris, Rat, Chien, Cheval, Boeuf (Vache), Cobaye, Lapin et Poisson zèbre (Danio rerio).

Aperçu rapide pour PEN2 anticorps (C-Term) (ABIN2788066)

Antigène: PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))

Reactivité: Humain, Souris, Rat, Chien, Cheval, Boeuf (Vache), Cobaye, Lapin, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PEN2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-PEN2 anticorps

Épitope: C-Term

Séquence: SQIKGYVWRS AVGFLFWVIV LTSWITIFQI YRPRWGALGD YLSFTIPLGT

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against PSENEN. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human PSENEN

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 101 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur PEN2

Antigène: PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))

Autre désignation: PSENEN

Sujet: Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase.
Alias Symbols: MDS033, MSTP064, PEN-2, PEN2
Protein Interaction Partner: APH1A, ERLIN2, THBD, APH1B, PSEN2, PSEN1, TMED10, NCSTN,
Protein Size: 101

Poids moléculaire: 12 kDa

ID gène: 55851

NCBI Accession: NM_172341, NP_758844

UniProt: Q9NZ42

Pathways: Signalisation Notch, Neurotrophin Signaling Pathway