RASSF5 anticorps (C-Term)

N° du produit ABIN2788157

Détail du produit anti-RASSF5 anticorps

Antigène: RASSF5 (Ras Association (RalGDS/AF-6) Domain Family Member 5 (RASSF5))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RASSF5 est non-conjugé

Application: Western Blotting (WB)

Séquence: SFVLKENETG EVEWDAFSIP ELQNFLTILE KEEQDKIHQL QKKYNKFRQK

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 86%, Rabbit: 100%, Rat: 92%

Attributs du produit: This is a rabbit polyclonal antibody against Rassf5. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C-terminal region of Mouse Rassf5

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeat freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur RASSF5

Antigène: RASSF5 (Ras Association (RalGDS/AF-6) Domain Family Member 5 (RASSF5))

Autre désignation: Rassf5 (RASSF5 Produits)

Synonymes: anticorps Maxp1, anticorps NORE1, anticorps NORE1A, anticorps NORE1B, anticorps RAPL, anticorps RASSF3, anticorps 1300019G20Rik, anticorps AU042887, anticorps Nore1, anticorps Nore1A, anticorps Nore1B, anticorps Rapl, anticorps Ras association domain family member 5, anticorps Ras association (RalGDS/AF-6) domain family member 5, anticorps RASSF5, anticorps Rassf5

Sujet: Rassf5 is a potental tumor suppressor. It seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. It may be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS1 and KRAS induced apoptosis.
Alias Symbols: 1300019G20Rik, AU042887, Maxp1, Nore1, Nore1A, Nore1B, Rapl
Protein Interaction Partner: Hras,
Protein Size: 413

Poids moléculaire: 47 kDa

ID gène: 54354

NCBI Accession: NM_018750, NP_061220

UniProt: Q5EBH1

Pathways: TCR Signaling