RASGRP4 anticorps (N-Term)

N° du produit ABIN2789029

Cet anticorps Lapin Polyclonal détecte spécifiquement RASGRP4 dans WB. Il présente une réactivité envers Humain et Porc.

Aperçu rapide pour RASGRP4 anticorps (N-Term) (ABIN2789029)

Antigène: RASGRP4 (RAS Guanyl Releasing Protein 4 (RASGRP4))

Reactivité: Humain, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RASGRP4 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-RASGRP4 anticorps

Épitope: N-Term

Séquence: FWATVAREGN SAQRRLGDSS DLLSPGGPGP PLPMSSPGLG KKRKVSLLFD

Homologie: Human: 100%, Pig: 92%

Attributs du produit: This is a rabbit polyclonal antibody against RASGRP4. It was validated on Western Blot.

Purification: Affinity Purified

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 576 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur RASGRP4

Antigène: RASGRP4 (RAS Guanyl Releasing Protein 4 (RASGRP4))

Autre désignation: RASGRP4

Sujet: The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: -
Protein Interaction Partner: HRAS, RAP1A,
Protein Size: 576

Poids moléculaire: 63 kDa

ID gène: 115727

NCBI Accession: NM_001146207, NP_001139679

UniProt: C0LTP7

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling