ABI1 anticorps (C-Term)

N° du produit ABIN2789495

L’anticorps anti-ABI1 Polyclonal Lapin est utilisé pour la détection de ABI1 dans des échantillons de Humain, Souris, Rat, Cheval, Lapin, Boeuf (Vache), Cobaye, Chien et Poisson zèbre (Danio rerio). Il a été validé pour WB.

Aperçu rapide pour ABI1 anticorps (C-Term) (ABIN2789495)

Antigène: ABI1 (Abl-Interactor 1 (ABI1))

Reactivité: Humain, Souris, Rat, Cheval, Lapin, Boeuf (Vache), Cobaye, Chien, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ABI1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-ABI1 anticorps

Épitope: C-Term

Fonction: ABI1 Antibody - C-terminal region

Séquence: IEKVVAIYDY TKDKDDELSF MEGAIIYVIK KNDDGWYEGV CNRVTGLFPG

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against ABI1. It was validated on Western Blot.

Purification: Affinity Purified

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP63430-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur ABI1

Antigène: ABI1 (Abl-Interactor 1 (ABI1))

Autre désignation: ABI1

Sujet:

Background Information: This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10,11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14.

Gene Name: Abl-interactor 1

Alternative Symbols: E3B1, ABI-1, ABLBP4, NAP1BP, SSH3BP, SSH3BP1

Protein Name: Abl-interactor 1 variant 72 EMBL ACJ12785.1

Poids moléculaire: 42kDa

ID gène: 10006

NCBI Accession: NP_001171595

UniProt: B6VEX5

Pathways: Signalisation RTK, Response to Water Deprivation, ER-Nucleus Signaling