Sortilin 1 anticorps (C-Term)

N° du produit ABIN2789904

Détail du produit anti-Sortilin 1 anticorps

Antigène: Sortilin 1 (SORT1)

Épitope: C-Term

Reactivité: Humain, Rat, Souris, Chien, Boeuf (Vache), Cobaye, Cheval, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Sortilin 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: YVCGGRFLVH RYSVLQQHAE ANGVDGVDAL DTASHTNKSG YHDDSDEDLL

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 86%, Rabbit: 93%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against SORT1. It was validated on Western Blot.

Purification: Affinity Purified

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 831 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Sortilin 1

Antigène: Sortilin 1 (SORT1)

Autre désignation: SORT1 (SORT1 Produits)

Synonymes: anticorps SORT1, anticorps 19.m02079, anticorps gp95, anticorps ldlcq6, anticorps sortilin, anticorps Gp95, anticorps LDLCQ6, anticorps NT3, anticorps 2900053A11Rik, anticorps AI852375, anticorps Ntr3, anticorps Ntsr3, anticorps Nt3, anticorps Nts3, anticorps sort1, anticorps zgc:85953, anticorps sortilin 1, anticorps sortilin, anticorps sortilin 1 S homeolog, anticorps sortilin 1a, anticorps SORT1, anticorps TP01_0016, anticorps BBOV_I002730, anticorps sort1.S, anticorps Sort1, anticorps sort1a

Sujet: This gene encodes a protein that is a multi-ligand type-1 receptor with similarity to the yeast carboxypeptidase Y sorting receptor Vps10 protein. The encoded protein, a trans-Golgi network (TGN) transmembrane protein, binds a number of unrelated ligands that participate in a wide range of cellular processes, however, it lacks the typical features of a signalling receptor. In the TGN, furin mediates the activation of the mature binding form. The encoded protein consists of a large luminal domain, a single transmembrane segment and short C-terminal cytoplasmic tail. The luminal domain contains a cysteine-rich region similar to two corresponding segments in the yeast Vps10p, the cytoplasmic tail is similar to the corresponding segment of the cation-independent mannose 6-phosphate receptor and the tail also interacts with the VHS domains of GGA (Golgi-associated, gamma-adaptin homologous, ARF-interacting) proteins.
Alias Symbols: Gp95, NT3
Protein Interaction Partner: NUDCD3, UBC, SORCS1, GGA1, GGA3, GGA2, STAM, ELAVL1, NTS, NGF, NGFR, BDNF, LRPAP1, CDK2, SLC2A4,
Protein Size: 831

Poids moléculaire: 84 kDa

ID gène: 6272

NCBI Accession: NM_002959, NP_002950

UniProt: Q99523

Pathways: Neurotrophin Signaling Pathway