CCDC98 anticorps (C-Term)

N° du produit ABIN2790106

Détail du produit anti-CCDC98 anticorps

Antigène: CCDC98 (FAM175A) (Family with Sequence Similarity 175, Member A (FAM175A))

Épitope: C-Term

Reactivité: Humain, Cheval, Lapin, Boeuf (Vache), Chien, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CCDC98 est non-conjugé

Application: Western Blotting (WB)

Séquence: DDRWQFKRSR LLDTQDKRSK ADTGSSNQDK ASKMSSPETD EEIEKMKGFG

Homologie: Cow: 85%, Dog: 79%, Horse: 100%, Human: 100%, Pig: 79%, Rabbit: 100%

Attributs du produit: This is a rabbit polyclonal antibody against FAM175A. It was validated on Western Blot.

Purification: Affinity Purified

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 409 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur CCDC98

Antigène: CCDC98 (FAM175A) (Family with Sequence Similarity 175, Member A (FAM175A))

Autre désignation: FAM175A (FAM175A Produits)

Synonymes: anticorps CCDC98, anticorps abra1, anticorps ccdc98, anticorps fam175a, anticorps ABRA1, anticorps 3830405G04Rik, anticorps 5630400M01Rik, anticorps AI506069, anticorps AL024423, anticorps AV118690, anticorps Ccdc98, anticorps RGD1305287, anticorps zgc:103522, anticorps abraxas 1, BRCA1 A complex subunit, anticorps Coiled-coil domain-containing protein 98, anticorps BRCA1 A complex subunit, anticorps family with sequence similarity 175 member A, anticorps abraxas 2a, BRISC complex subunit, anticorps abraxas 1, BRCA1 A complex subunit S homeolog, anticorps ABRAXAS1, anticorps abraxas1, anticorps Abraxas1, anticorps FAM175A, anticorps abraxas2a, anticorps abraxas1.S

Sujet: FAM175A is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1.
Alias Symbols: ABRA1, CCDC98, FLJ11520, FLJ12642, FLJ13614
Protein Interaction Partner: FANCG, UIMC1, BRCA1, BRCC3, BABAM1, UBC, SUMO2, PAXIP1, MDC1, BARD1, BRE, HSPA4,
Protein Size: 409

Poids moléculaire: 47 kDa

ID gène: 84142

NCBI Accession: NM_139076, NP_620775

UniProt: Q6UWZ7

Pathways: Réparation de l'ADN, Positive Regulation of Response to DNA Damage Stimulus