CCDC98 anticorps (N-Term)

N° du produit ABIN499595

Détail du produit anti-CCDC98 anticorps

Antigène: CCDC98 (FAM175A) (Family with Sequence Similarity 175, Member A (FAM175A))

Épitope: N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CCDC98 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts to CCDC98.

Purification: Affinity chromatography purified via peptide column

Immunogène: CCDC98 antibody was raised against a 15 amino acid peptide from near the amino terminus of human CCDC98.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: CCDC98 antibody can be used for detection of CCDC98 at 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur CCDC98

Antigène: CCDC98 (FAM175A) (Family with Sequence Similarity 175, Member A (FAM175A))

Autre désignation: CCDC98 (FAM175A Produits)

Synonymes: anticorps CCDC98, anticorps abra1, anticorps ccdc98, anticorps fam175a, anticorps ABRA1, anticorps 3830405G04Rik, anticorps 5630400M01Rik, anticorps AI506069, anticorps AL024423, anticorps AV118690, anticorps Ccdc98, anticorps RGD1305287, anticorps zgc:103522, anticorps abraxas 1, BRCA1 A complex subunit, anticorps Coiled-coil domain-containing protein 98, anticorps BRCA1 A complex subunit, anticorps family with sequence similarity 175 member A, anticorps abraxas 2a, BRISC complex subunit, anticorps abraxas 1, BRCA1 A complex subunit S homeolog, anticorps ABRAXAS1, anticorps abraxas1, anticorps Abraxas1, anticorps FAM175A, anticorps abraxas2a, anticorps abraxas1.S

Sujet: CCDC98, also known as Abraxas 1, was identified through protein binding studies using the breast and ovarian predisposition protein BRCA1 as the binding target. CCDC98 recruits RAP80, a ubiquitin-binding protein, to BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both CCDC98 and RAP80 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either CCDC98 or RAP80 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that CCDC98 and RAP80 control only part of the DNA damage response role of BRCA1. At least two isoforms of CCDC98 are known to exist.Synonyms: ABRA1, Abraxas, BRCA1-A complex subunit Abraxas, Coiled-coil domain-containing protein 98, Protein FAM175A

ID gène: 84142

NCBI Accession: NP_620775

UniProt: Q6UWZ7

Pathways: Réparation de l'ADN, Positive Regulation of Response to DNA Damage Stimulus