YWHAE anticorps (Middle Region)

N° du produit ABIN2792142

Cet anticorps anti-YWHAE est un anticorps Lapin Polyclonal détectant YWHAE dans WB. Adapté pour Souris, Poisson zèbre (Danio rerio), Cobaye et Chien. Ce Primary Antibody a été cité dans 1 publication.

Aperçu rapide pour YWHAE anticorps (Middle Region) (ABIN2792142)

Antigène: YWHAE (14-3-3 epsilon (YWHAE))

Reactivité: Souris, Poisson zèbre (Danio rerio), Cobaye, Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp YWHAE est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-YWHAE anticorps

Épitope: Middle Region

Séquence: ELDTLSEESY KDSTLIMQLL RDNLTLWTSD MQGDGEEQNK EALQDVEDEN

Homologie: Dog: 100%, Guinea Pig: 100%, Mouse: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against YWHAE. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human YWHAE

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 255 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-YWHAE (ABIN2792142)

Tak, Jang, Kim, Park, Suk, Yoon, Ahn, Lee, Joe: "14-3-3epsilon inhibits MK5-mediated cell migration by disrupting F-actin polymerization." dans: Cellular signalling, Vol. 19, Issue 11, pp. 2379-87, (2007) (PubMed).

Détails sur YWHAE

Antigène: YWHAE (14-3-3 epsilon (YWHAE))

Autre désignation: YWHAE

Sujet: YWHAE is an adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. YWHAE binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. The binding generally results in the modulation of the activity of the binding partner.This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100 % identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: 14-3-3E, FLJ45465, KCIP-1, MDCR, MDS
Protein Interaction Partner: DTL, HUWE1, FAM53C, FBXW11, SORBS2, UBC, ABL1, GRB10, SIK2, CEP57, SIK3, TP53, IRS4, CBL, TUBB2A, TWF2, PROSC, FERMT2, PDIA4, RAP1GDS1, PTMA, PPP1R2, PDHB, PAK2, PAFAH1B2, YWHAH, XPO1, VCL, GSS, G6PD, EIF5, TBCB, CAPNS1, CAPN2, ALDH7A1, ATIC, ASNS, SCPEP1
Protein Size: 255

Poids moléculaire: 29 kDa

ID gène: 7531

NCBI Accession: NM_006761, NP_006752

UniProt: P62258

Pathways: Neurotrophin Signaling Pathway, Myometrial Relaxation and Contraction, M Phase