Cyclin H anticorps (C-Term)

N° du produit ABIN2792161

Cet anticorps anti-Cyclin H Polyclonal Lapin (ABIN2792161) détecte spécifiquement Cyclin H dans WB et IHC. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Cobaye, Lapin et Cheval.

Aperçu rapide pour Cyclin H anticorps (C-Term) (ABIN2792161)

Antigène: Cyclin H (CCNH)

Reactivité: Humain, Souris, Rat, Cobaye, Lapin, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cyclin H est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Cyclin H anticorps

Épitope: C-Term

Fonction: CCNH Antibody - C-terminal region

Séquence: KQKLERCHSA ELALNVITKK RKGYEDDDYV SKKSKHEEEE WTDDDLVESL

Homologie: Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 83%, Rabbit: 83%, Rat: 83%

Attributs du produit: This is a rabbit polyclonal antibody against CCNH. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human CCNH

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur Cyclin H

Antigène: Cyclin H (CCNH)

Autre désignation: CCNH

Sujet:

Background Information: Cyclin H regulates CDK7, the catalytic subunit of the CDK- activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDC2/CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive carboxyl-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. It is involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

Gene Name: Cyclin H

Alternative Symbols: CAK, p34, p37, CycH

Protein Name: Cyclin-H

Poids moléculaire: 38 kDa

ID gène: 902

NCBI Accession: NP_001230

UniProt: P51946

Pathways: Cycle Cellulaire, Mitotic G1-G1/S Phases, M Phase