Topoisomerase II alpha anticorps (C-Term)

N° du produit ABIN2792181

Détail du produit anti-Topoisomerase II alpha anticorps

Antigène: Topoisomerase II alpha (TOP2A) (Topoisomerase (DNA) II alpha 170kDa (TOP2A))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Porc, Chien, Lapin, Cheval, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Topoisomerase II alpha est non-conjugé

Application: Western Blotting (WB)

Séquence: VSKAVTSKKS KGESDDFHMD FDSAVAPRAK SVRAKKPIKY LEESDEDDLF

Homologie: Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 87%, Pig: 100%, Rabbit: 100%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against TOP2A. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human TOP2A

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 1531 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Topoisomerase II alpha

Antigène: Topoisomerase II alpha (TOP2A) (Topoisomerase (DNA) II alpha 170kDa (TOP2A))

Autre désignation: TOP2A (TOP2A Produits)

Synonymes: anticorps TOP2, anticorps TP2A, anticorps TOP2A, anticorps Top-2, anticorps TOP-2, anticorps F12B17.110, anticorps F12B17_110, anticorps thimet metalloendopeptidase 2, anticorps fc08c07, anticorps wu:fc08c07, anticorps DNA topoisomerase II alpha, anticorps DNA topoisomerase II, alpha isozyme, anticorps topoisomerase (DNA) II alpha, anticorps Zincin-like metalloproteases family protein, anticorps TOP2A, anticorps Bm1_08705, anticorps Top2a, anticorps AT5G10540, anticorps top2a

Sujet: TOP2A is a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromsome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.
Alias Symbols: TOP2, TP2A
Protein Interaction Partner: UBC, SUMO2, SUMO3, EIF6, RPA3, RPA2, RPA1, SUMO1, LMNA, CTNNB1, ITGA4, FN1, CSNK2A1, VCAM1, SRPK1, RB1, ESR1, TOP2B, CSNK2A2, UPF3B, PRKCG, PRKCB, PRKCA, TERF2, BLM, NEDD8, COPS5, CUL5, FBXW7, ISG15, CUL2, VHL, TCEB1, GSK3B, SUMO4, SMARCAD1, CTCF, RING1,
Protein Size: 1531

Poids moléculaire: 174 kDa

ID gène: 7153

NCBI Accession: NM_001067, NP_001058

UniProt: P11388

Pathways: Cycle Cellulaire, Mitotic G1-G1/S Phases