CHRNB3 anticorps (Middle Region)

N° du produit ABIN2792254

Cet anticorps Lapin Polyclonal détecte spécifiquement CHRNB3 dans WB. Il présente une réactivité avec des échantillons de Souris, Rat, Chien, Cobaye, Boeuf (Vache), Cheval et Lapin.

Aperçu rapide pour CHRNB3 anticorps (Middle Region) (ABIN2792254)

Antigène: CHRNB3 (Cholinergic Receptor, Nicotinic, beta 3 (Neuronal) (CHRNB3))

Reactivité: Souris, Rat, Chien, Cobaye, Boeuf (Vache), Cheval, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CHRNB3 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-CHRNB3 anticorps

Épitope: Middle Region

Séquence: YDGTMVDLIL INENVDRKDF FDNGEWEILN AKGMKGNRRD GVYSYPFITY

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against CHRNB3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human CHRNB3

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 458 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur CHRNB3

Antigène: CHRNB3 (Cholinergic Receptor, Nicotinic, beta 3 (Neuronal) (CHRNB3))

Autre désignation: CHRNB3

Sujet: Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels nAChRs are pentameric structures that are made up of combinations of individual subunits. CHRNB3 is one of the subunits of nAChR. Twelve neuronal nAChR subunits have been described, alpha2-alpha10 and beta2-beta4. CHRNB3 decreased the channel mean open time and burst length. There was also an increase in single channel slope conductance. On the other hand, the calcium permeability and the pharmacological properties of beta3-containing receptors differed little from those of without beta3. Dysfunction of nAChR has been linked to a number of human diseases such as schizophrenia, Alzheimer's and Parkinson's diseases. nAChRs also play a significant role in nicotine addiction.
Protein Size: 458

Poids moléculaire: 53 kDa

ID gène: 1142

NCBI Accession: NM_000749, NP_000740

UniProt: Q05901