NFX1 anticorps (Middle Region)

N° du produit ABIN2792551

L’anticorps anti-NFX1 Polyclonal Lapin est utilisé pour la détection de NFX1 dans des échantillons de Humain, Souris, Rat, Chien, Lapin et Boeuf (Vache). Il a été validé pour WB et IHC.

Aperçu rapide pour NFX1 anticorps (Middle Region) (ABIN2792551)

Antigène: NFX1 (Nuclear Transcription Factor, X-Box Binding 1 (NFX1))

Reactivité: Humain, Souris, Rat, Chien, Lapin, Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NFX1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-NFX1 anticorps

Épitope: Middle Region

Fonction: NFX1 Antibody - middle region

Séquence: TLTGVLEREM QARPPPPIPH HRHQSDKNPG SSNLQKITKE PIIDYFDVQD

Réactivité croisée: Boeuf (Vache), Chien, Humain, Souris, Rat (Rattus)

Homologie: Cow: 85%, Dog: 85%, Human: 100%, Mouse: 76%, Rabbit: 85%, Rat: 85%

Attributs du produit: This is a rabbit polyclonal antibody against NFX1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human NFX1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur NFX1

Antigène: NFX1 (Nuclear Transcription Factor, X-Box Binding 1 (NFX1))

Autre désignation: NFX1

Sujet:

Background Information: MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. NFX1 is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma.MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified.

Gene Name: Nuclear transcription factor, X-box binding 1

Alternative Symbols: NFX2, Tex42, TEG-42

Protein Name: Transcriptional repressor NF-X1

Poids moléculaire: 124kDa

ID gène: 4799

NCBI Accession: NP_002495

UniProt: Q12986