Cyclin H anticorps (Middle Region)

N° du produit ABIN2792693

Cet anticorps Lapin Polyclonal détecte spécifiquement Cyclin H dans WB. Il présente une réactivité envers Humain, Souris, Rat, Cobaye, Lapin, Cheval et Boeuf (Vache).

Aperçu rapide pour Cyclin H anticorps (Middle Region) (ABIN2792693)

Antigène: Cyclin H (CCNH)

Reactivité: Humain, Souris, Rat, Cobaye, Lapin, Cheval, Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cyclin H est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Cyclin H anticorps

Épitope: Middle Region

Séquence: KQKLERCHSA ELALNVITKK RKGYEDDDYV SKKSKHEEEE WTDDDLVESL

Réactivité croisée: Boeuf (Vache), Humain, Souris, Porc, Rat (Rattus)

Homologie: Cow: 100%, Guinea Pig: 100%, Horse: 92%, Human: 100%, Mouse: 85%, Rabbit: 78%, Rat: 85%

Attributs du produit: This is a rabbit polyclonal antibody against CCNH. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human CCNH

Information d'application

Indications d'application: WB Suggested Anti-CCNH Antibody Titration: 0.2-1 µg/mL
ELISA Titer: 1:1562500
Positive Control: MCF7 cell lysate.
Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 323 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Cyclin H

Antigène: Cyclin H (CCNH)

Autre désignation: Cyclin H

Sujet: CCNH belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery.The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CAK, p34, p37
Protein Interaction Partner: SFN, GOLGA2, SSX2IP, CCDC170, CCDC33, DUSP12, SSSCA1, NDC80, CALCOCO2, PPFIA1, PSMA1, KLC3, RPA3, RPA2, RPA1, NEDD4, CDK7, CDK8, CDK2, CCNC, MNAT1, MBP, CTD, CDK20, CTBP2, CSNK2B, TRIM8, GANAB, RARB, POLR2A, GTF2H4, ERCC2, tat, POLR2B, CDK9, BRCA1, GTF2H1
Protein Size: 323

Poids moléculaire: 38 kDa

ID gène: 902

NCBI Accession: NM_001239, NP_001230

UniProt: P51946

Pathways: Cycle Cellulaire, Mitotic G1-G1/S Phases, M Phase