Neuregulin 3 anticorps (C-Term)

N° du produit ABIN2794837

Cet anticorps Lapin Polyclonal détecte spécifiquement Neuregulin 3 dans WB et IHC. Il présente une réactivité envers Humain.

Aperçu rapide pour Neuregulin 3 anticorps (C-Term) (ABIN2794837)

Antigène: Neuregulin 3 (NRG3)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Neuregulin 3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Neuregulin 3 anticorps

Épitope: AA 688-717, C-Term

Fonction: Rabbit Anti-Human NRG3 (C-term) Antibody

Immunogène: This NRG3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 688-717 amino acids from the C-terminal region of human NRG3.

Isotype: Ig Fraction

Information d'application

Indications d'application: Western Blot, Immunohistochemistry
Recommended Dilutions
WB: 1:1000, IHC: 1:10-50NRG3 Antibody (E703) for immunohistochemistry. Clinical relevance has not been evaluated.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C (short-term), -20°C (long-term)

Détails sur Neuregulin 3

Antigène: Neuregulin 3 (NRG3)

Autre désignation: NRG3

Sujet:

Target Description: NRG3, which belongs to the neuregulin family, is a direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. NRG3 does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. The protein exists as an type I membrane protein and as a proteolytically released soluble growth factor form. The membrane-bound form does not appear to be active. NRG3 is highly expressed in most regions of the brain with the exception of corpus callosum, and is expressed at lower level in testis. It is not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes. The NRG3 cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing may involve initial intracellular domain dimerization.

Gene Symbol: NRG3

Poids moléculaire: 77901 Da

ID gène: 10718

UniProt: P56975

Pathways: Signalisation RTK