UBD anticorps (AA 60-100) (AbBy Fluor® 594)

N° du produit ABIN2807361

Cet anticorps Lapin Polyclonal détecte spécifiquement UBD dans WB. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour UBD anticorps (AA 60-100) (AbBy Fluor® 594) (ABIN2807361)

Antigène: UBD (Ubiquitin D (UBD))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UBD est conjugé à/à la AbBy Fluor® 594

Application: Western Blotting (WB)

Détail du produit anti-UBD anticorps (AbBy Fluor® 594)

Épitope: AA 60-100

Réactivité croisée: Souris, Rat

Homologie: Human,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Ubiquitin D

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur UBD

Antigène: UBD (Ubiquitin D (UBD))

Autre désignation: Ubiquitin D

Sujet:

Synonyms: FAT10, UBD-3, GABBR1, Ubiquitin D, Diubiquitin, Ubiquitin-like protein FAT10, UBD

Background: Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1L-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease and Human immunodeficiency virus (HIV)-associated nephropathy (HIVAN).

ID gène: 10537

UniProt: O15205

Pathways: Ubiquitin Proteasome Pathway