Aspartate beta Hydroxylase anticorps (AA 301-400) (AbBy Fluor® 594)

N° du produit ABIN2810000

Cet anticorps anti-Aspartate beta Hydroxylase est un anticorps Lapin Polyclonal détectant Aspartate beta Hydroxylase dans IF (cc) et IF (p). Adapté pour Humain.

Aperçu rapide pour Aspartate beta Hydroxylase anticorps (AA 301-400) (AbBy Fluor® 594) (ABIN2810000)

Antigène: Aspartate beta Hydroxylase (ASPH) (Aspartate beta-Hydroxylase (ASPH))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Aspartate beta Hydroxylase est conjugé à/à la AbBy Fluor® 594

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-Aspartate beta Hydroxylase anticorps (AbBy Fluor® 594)

Épitope: AA 301-400

Homologie: Human,Mouse,Rat,Cow,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human ASPH/Aspartate beta hydroxylase

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur Aspartate beta Hydroxylase

Antigène: Aspartate beta Hydroxylase (ASPH) (Aspartate beta-Hydroxylase (ASPH))

Autre désignation: ASPH/Aspartate beta hydroxylase

Sujet:

Synonyms: ASP beta hydroxylase, Aspartyl/asparaginyl beta hydroxylase, ASPH, BAH, CASQ2BP1, HAAH, JCTN, junctin, Peptide aspartate beta dioxygenase, ASPH_HUMAN.

Background: Aspartyl/asparaginyl beta-hydroxylase (ASPH) is a widely-expressed type II membrane protein involved in calcium homeostasis. Located in the endoplasmic reticulum, ASPH specifically hydroxylates an Asp or Asn residue in the epidermal growth factor-like (EGF) domains of several proteins, using iron as a cofactor. The ASPH gene encodes 3 proteins, ASPH, Junctin, and Junctate (or Humbug), that differ significantly in their C-terminal domains. These ASPH gene products are expressed as five transcript variants that differ by their roles in calcium storage and release, hydroxylation capabilities, and tissue specificity. While all ASPH variants are expressed in skeletal muscle, only some are detected in heart, brain, pancreas, placenta, lung, liver, and kidney tissues. In the lumen of the endoplasmic reticulum, ASPH can be processed into two different forms.

Pathways: Positive Regulation of Endopeptidase Activity