Growth Hormone Receptor anticorps

N° du produit ABIN2854312

Cet anticorps Lapin Polyclonal détecte spécifiquement Growth Hormone Receptor dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Growth Hormone Receptor anticorps (ABIN2854312)

Antigène: Growth Hormone Receptor (GHR)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Growth Hormone Receptor est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-Growth Hormone Receptor anticorps

Réactivité croisée: Humain

Attributs du produit: Rabbit Polyclonal antibody to Growth hormone Receptor (growth hormone receptor)
Growth hormone Receptor antibody [N3C2], Internal

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the center region of human Growth hormone Receptor. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.7 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détails sur Growth Hormone Receptor

Antigène: Growth Hormone Receptor (GHR)

Autre désignation: growth hormone receptor

Sujet: This gene encodes a protein that is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. Other splice variants, including one encoding a soluble form of the protein (GHRtr), have been observed but have not been thoroughly characterized. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. The precise location of this cleavage site has not been determined for the human protein.

Cellular Localization: Cell membrane, Single-pass type I membrane protein , Isoform 2: Cell membrane, Single-pass type I membrane protein , Growth hormone-binding protein: Secreted

Poids moléculaire: 72 kDa

ID gène: 2690

UniProt: P10912

Pathways: Signalisation NF-kappaB, Signalistation JAK/STAT, Response to Growth Hormone Stimulus