NUP98 anticorps

N° du produit ABIN2854401

Cet anticorps anti-NUP98 est un anticorps Lapin Polyclonal détectant NUP98 dans WB. Adapté pour Humain.

Aperçu rapide pour NUP98 anticorps (ABIN2854401)

Antigène: NUP98 (Nucleoporin 98kDa (NUP98))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NUP98 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-NUP98 anticorps

Réactivité croisée: Singe

Attributs du produit: Rabbit polyclonal antibody to NUP98 (nucleoporin 98 kDa)
NUP98 antibody [N1N2], N-term

Purification: Affinity purified by Protein A.

Immunogène: Recombinant protein encompassing a sequence within the center region of human NUP98. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: cos 7

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.39 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détails sur NUP98

Antigène: NUP98 (Nucleoporin 98kDa (NUP98))

Autre désignation: nucleoporin 98

Sujet: Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kD nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kD precursor protein. This cleavage results in the 98 kD nucleoporin as well as a 96 kD nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromsome translocatons in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants, however, not all variants have been fully described.

Cellular Localization: Nucleus , nuclear pore complex , Nucleus membrane, Peripheral membrane protein, Nucleoplasmic side

Poids moléculaire: 198 kDa

ID gène: 4928

UniProt: P52948

Pathways: Stem Cell Maintenance, Protein targeting to Nucleus, SARS-CoV-2 Protein Interactome