IL12RB2 anticorps

N° du produit ABIN2854423

Cet anticorps Lapin Polyclonal détecte spécifiquement IL12RB2 dans WB. Il présente une réactivité envers Humain.

Aperçu rapide pour IL12RB2 anticorps (ABIN2854423)

Antigène: IL12RB2 (Interleukin 12 Receptor, beta 2 (IL12RB2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IL12RB2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-IL12RB2 anticorps

Réactivité croisée: Humain

Attributs du produit: Rabbit polyclonal antibody to IL-12 Receptor beta2 (interleukin 12 receptor, beta 2)
IL-12 Receptor beta2 antibody [N3C2], Internal

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the center region of human IL12 Receptor beta2. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:1000-1:10000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: A431 , HepG2

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détails sur IL12RB2

Antigène: IL12RB2 (Interleukin 12 Receptor, beta 2 (IL12RB2))

Autre désignation: interleukin 12 receptor subunit beta 2

Sujet: The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense.

Cellular Localization: Membrane, Single-pass type I membrane protein

Poids moléculaire: 97 kDa

ID gène: 3595

UniProt: Q99665

Pathways: Signalistation JAK/STAT