DDR2 anticorps (C-Term)

N° du produit ABIN2855450

L’anticorps Lapin Polyclonal anti-DDR2 a été validé pour WB, IHC (p), ICC et IF. Il convient pour détecter DDR2 dans des échantillons de Humain.

Aperçu rapide pour DDR2 anticorps (C-Term) (ABIN2855450)

Antigène: DDR2 (Discoidin Domain Receptor tyrosine Kinase 2 (DDR2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DDR2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (IF)

Classe de qualité: KO Validated

Détail du produit anti-DDR2 anticorps

Épitope: C-Term

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Rabbit Polyclonal antibody to DDR2 (discoidin domain receptor tyrosine kinase 2)
DDR2 antibody [C2C3], C-term

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the C-terminus region of human DDR2. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:1000-1:10000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Validation: KO/KD, Overexpression

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.43 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détails sur DDR2

Antigène: DDR2 (Discoidin Domain Receptor tyrosine Kinase 2 (DDR2))

Autre désignation: discoidin domain receptor tyrosine kinase 2

Sujet: Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein.

Cellular Localization: Membrane

Poids moléculaire: 97 kDa

ID gène: 4921

UniProt: Q16832

Pathways: Signalisation RTK