XPC anticorps (C-Term)

N° du produit ABIN2855495

Détail du produit anti-XPC anticorps

Antigène: XPC (Xeroderma Pigmentosum, Complementation Group C (XPC))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp XPC est non-conjugé

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Réactivité croisée: Rat (Rattus)

Réactivité croisée (Details): Rat (85 %)

Attributs du produit: Rabbit Polyclonal antibody to XPC (xeroderma pigmentosum, complementation group C)
XPC antibody [C2C3], C-term

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the C-terminus region of human XPC. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: Suggested dilution Reference ICC/IF 1:100-1:1000* IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceICC/IF1:100-1:1000* IHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Western blot1:500-1:3000*

Commentaires:

Positive Control: NT2D1 , IMR32 , U87-MG , MCF-7

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.67 mg/mL

Buffer: 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Références pour anticorps anti-XPC (ABIN2855495)

Lemoine, Bayrambey, Roloff, Hutzler, Luch, Tralau: "Commensal-Related Changes in the Epidermal Barrier Function Lead to Alterations in the Benzo[a]Pyrene Metabolite Profile and Its Distribution in 3D Skin." dans: mBio, Vol. 12, Issue 5, pp. e0122321, (2022) (PubMed).

Détails sur XPC

Antigène: XPC (Xeroderma Pigmentosum, Complementation Group C (XPC))

Autre désignation: XPC (XPC Produits)

Synonymes: anticorps RAD4, anticorps XP3, anticorps XPCC, anticorps XPC complex subunit, DNA damage recognition and repair factor, anticorps xeroderma pigmentosum, complementation group C, anticorps XPC, anticorps Xpc

Sujet: This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.

Cellular Localization: Nucleus

Poids moléculaire: 106 kDa

ID gène: 7508

Pathways: Signalisation p53, Réparation de l'ADN