Lamin B1 anticorps

N° du produit ABIN2855607

Cet anticorps anti-Lamin B1 est un anticorps Lapin Polyclonal détectant Lamin B1 dans WB, IP et IHC (p). Adapté pour Humain. Ce Primary Antibody a été cité dans 4+ publications.

Aperçu rapide pour Lamin B1 anticorps (ABIN2855607)

Antigène: Lamin B1 (LMNB1)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Lamin B1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: KO Validated

Détail du produit anti-Lamin B1 anticorps

Réactivité croisée: Hamster, Humain, Souris

Attributs du produit: Rabbit Polyclonal antibody to Lamin B1 (lamin B1)
Lamin B1 antibody

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the center region of human Lamin B1. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:20000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Validatio: KO/KD, Orthogonal

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Références pour anticorps anti-Lamin B1 (ABIN2855607)

Siew, Chen, Chen, Chen, Chen, Soong, Wu, Chang, Chan, Lin, Liu, Chern: "Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington's disease." dans: Nature communications, Vol. 10, Issue 1, pp. 3473, (2019) (PubMed).

Silva, Pentz, Figueira, Arora, Lee, Hodson, Wischnewski, Deans, Azzalin: "FANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loops." dans: Nature communications, Vol. 10, Issue 1, pp. 2253, (2019) (PubMed).

Hsieh, Wang, Changou, Chin, Yang, Lai, Lee, Yang, Whang-Peng, Liu, Lin, Mousa, Davis: "Crosstalk between integrin αvβ3 and ERα contributes to thyroid hormone-induced proliferation of ovarian cancer cells." dans: Oncotarget, Vol. 8, Issue 15, pp. 24237-24249, (2018) (PubMed).

Arora, Lee, Wischnewski, Brun, Schwarz, Azzalin: "RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells." dans: Nature communications, Vol. 5, pp. 5220, (2014) (PubMed).

Détails sur Lamin B1

Antigène: Lamin B1 (LMNB1)

Autre désignation: lamin B1

Sujet: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1.

Cellular Localization: Nucleus inner membrane, Lipid-anchor, Nucleoplasmic side

Poids moléculaire: 66 kDa

ID gène: 4001

UniProt: P20700

Pathways: Apoptose, Caspase Cascade in Apoptosis