RASGRP4 anticorps (N-Term)

N° du produit ABIN2855910

Cet anticorps anti-RASGRP4 est un anticorps Lapin Polyclonal détectant RASGRP4 dans WB, IHC (p), IF et ICC. Adapté pour Humain.

Aperçu rapide pour RASGRP4 anticorps (N-Term) (ABIN2855910)

Antigène: RASGRP4 (RAS Guanyl Releasing Protein 4 (RASGRP4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RASGRP4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Immunocytochemistry (ICC)

Détail du produit anti-RASGRP4 anticorps

Épitope: N-Term

Réactivité croisée: Humain

Attributs du produit: Rabbit Polyclonal antibody to RASGRP4 (RAS guanyl releasing protein 4)
RASGRP4 antibody [N1N2], N-term

Purification: Purified by antigen-affinity chromatography.

Immunogène: Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human RASGRP4. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: Jurkat

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1XPBS ( pH 7), 40 % Glycerol, 0.01 % Thimerosal

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détails sur RASGRP4

Antigène: RASGRP4 (RAS Guanyl Releasing Protein 4 (RASGRP4))

Autre désignation: RAS guanyl releasing protein 4

Sujet: The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene.

Cellular Localization: Cytoplasm , Cell membrane

Poids moléculaire: 75 kDa

ID gène: 115727

UniProt: Q8TDF6

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling