Phospholamban anticorps (phosphospecific)

N° du produit ABIN285884

Détail du produit anti-Phospholamban anticorps

Antigène: Phospholamban (PLN)

Épitope: AA 14-25, phosphospecific

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Phospholamban est non-conjugé

Application: Western Blotting (WB)

Réactivité croisée: Boeuf (Vache), Chien, Souris, Rat (Rattus)

Réactivité croisée (Details): Bovine, Predicted to cross-react with human, mouse, rat, rabbit, pig and dog.1 mg/ml

Purification: Protein A affinity chromatography

Immunogène: Phospho-Phospholamban antibody was raised in rabbit using a synthetic peptide conjugated to KLH, corresponding to amino acids 14-25 of human cardiac phospholamban (RA[pS]TIEMPQQAR-C) as the immunogen.

Isotype: IgG

Information d'application

Indications d'application: Optimal conditions should be determined byt he investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: 100 mM Tris-glycine, pH 7.4, with 150 M NaCl, 0.05 % NaN3 and 30 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Stock: -20 °C

Stockage commentaire: Aliquot and store at -20 °C.

Références pour anticorps anti-Phospholamban (ABIN285884)

Kushnir, Santulli, Reiken, Coromilas, Godfrey, Brunjes, Colombo, Yuzefpolskaya, Sokol, Kitsis, Marks: "Ryanodine Receptor Calcium Leak in Circulating B-Lymphocytes as a Biomarker in Heart Failure." dans: Circulation, Vol. 138, Issue 11, pp. 1144-1154, (2019) (PubMed).

Détails sur Phospholamban

Antigène: Phospholamban (PLN)

Autre désignation: Phospholamban (PLN Produits)

Sujet: Phospholamban (PLB) is a 52 amino acid phosphoprotein which regulates the calcium pump of cardiac sarcoplasmic reticulum (SR). PLB is an oligomer of five identical subunits each having a cytoplasmic and transmembrane domain. Following adrenergic stimulation of cardiac muscle, PLB is phosphorylated at Ser16 and at Thr17 which is correlated with stimulation of calcium transport activity across the SR membrane and relaxation of cardiac fibers.

Pathways: Negative Regulation of Transporter Activity