SNCAIP
Reactivité: Humain, Souris
WB
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
ELISA: >1:10,655, IHC-P: >1:400, WB: >1:2,000 Optimal conditions should be determined by the investigator.
Restrictions
For Research Use only
Format
Liquid
Concentration
Lot specific
Buffer
Supplied as liquid whole serum without preservative
Conseil sur la manipulation
Avoid repeated freeze/thaw cycles.
Stock
4 °C/-20 °C
Stockage commentaire
Store at 4 °C for short term storage. Aliquot and store at -20 °C for long term storage.
Antigène
SNCAIP
(Synuclein, alpha Interacting Protein (SNCAIP))
Autre désignation
Synphilin 1
Sujet
Synphilin-1 is a cytoplasmic protein that is enriched in the neurophil of normal human brain. Although the exact function of synphilin-1 is unknown, it may possibly have a role as a cytoskeletal protein based on the presence of ankyrin-like repeats and an ATP, GTP-binding domain. It has been shown to be novel is its ability to associate in vivo with a-synuclein to form cytoplasmic eosinophilic inclusions. Additionally, it has been observed to be present in Lewy bodies of Parkinson disease, which are composed of a-synuclein. Because synphilin-1 is not found in protein aggregates of Alzheimer’s disease, it appears to be specific for a-synuclein-containing lesions. Synphilin-1 may facilitate the aggregation of a-synuclein into Lewy bodies.