Beclin 1 anticorps

N° du produit ABIN2868739

Cet anticorps anti-Beclin 1 Polyclonal Lapin (ABIN2868739) détecte spécifiquement Beclin 1 dans WB, IF et ICC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Beclin 1 anticorps (ABIN2868739)

Antigène: Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Beclin 1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Détail du produit anti-Beclin 1 anticorps

Specificité: Predicted molecular weight at ~51 kDa. Observed a secondary band on some lysates at ~30 kDa.

Réactivité croisée: Humain, Rat

Purification: Peptide Affinity Purified

Immunogène: Synthetic peptide from the mid-protein of human Beclin 1

Information d'application

Indications d'application:

• WB (1:1000)
• ICC/IF (1:100)
• optimal dilutions for assays should be determined by the user.

Commentaires:

A 1:1000 dilution of ABIN2868739 was sufficient for detection of Beclin1 on HeLa cell lysates using Goat anti-rabbit IgG:HRP as the secondary antibody.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C

Détails sur Beclin 1

Antigène: Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

Autre désignation: Beclin 1

Sujet: Beclin 1 is the mammalian ortholog of the yeast autophagy -related gene Atg6. It regulates autophagy and has an important role in development, tumorigenesis and neurodegeneration (1). Beclin 1 is localized within cytoplasmic structures including the mitochondria, yet overexpression reveals some nuclear staining (2). Researchers have found that schizonphrenia is associated with low levels of Beclin-1 in the hippocampus (3). It may also protect against infection by a neuorvirulent strain of Sindbis virus (4).

ID gène: 8678

NCBI Accession: NP_001300927

UniProt: Q14457

Pathways: Autophagy