RUNX2 anticorps (AA 242-521)

N° du produit ABIN3016834

Cet anticorps anti-RUNX2 est un anticorps Lapin Polyclonal détectant RUNX2 dans WB, IHC et IF. Adapté pour Humain. Ce Primary Antibody a été cité dans 5+ publications.

Aperçu rapide pour RUNX2 anticorps (AA 242-521) (ABIN3016834)

Antigène: RUNX2 (Runt-Related Transcription Factor 2 (RUNX2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RUNX2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-RUNX2 anticorps

Épitope: AA 242-521

Séquence: FSDRLSDLGR IPHPSMRVGV PPQNPRPSLN SAPSPFNPQG QSQITDPRQA QSSPPWSYDQ SYPSYLSQMT SPSIHSTTPL SSTRGTGLPA ITDVPRRISD DDTATSDFCL WPSTLSKKSQ AGASELGPFS DPRQFPSISS LTESRFSNPR MHYPATFTYT PPVTSGMSLG MSATTHYHTY LPPPYPGSSQ SQSGPFQTSS TPYLYYGTSS GSYQFPMVPG GDRSPSRMLP PCTTTSNGST LLNPNLPNQN DGVDADGSHS SSPTVLNSSG RMDESVWRPY

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 242-521 of human RUNX2 (NP_001019801.3).

Isotype: IgG

Information d'application

Indications d'application: WB,1:200 - 1:1000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Références pour anticorps anti-RUNX2 (ABIN3016834)

Zhang, Wang, Zeng, Yan, Ouyang, Liu, Sun, Zhao, Fang, Pan, Xie, Yang, Zhang, Bai, Cai: "mTORC1 activation downregulates FGFR3 and PTH/PTHrP receptor in articular chondrocytes to initiate osteoarthritis." dans: Osteoarthritis and cartilage, Vol. 25, Issue 6, pp. 952-963, (2018) (PubMed).

Gao, Li, Li: "Exendin-4 promotes the osteogenic differentiation of osteoblasts via the Hedgehog/Gli1 signaling pathway." dans: American journal of translational research, Vol. 10, Issue 1, pp. 315-324, (2018) (PubMed).

Wang, Zhang, Sun, Wang, Yang, Yang, Zhang, Luo, Wang, Jiang, Zeng, Cai, Bai: "Intra-articular Delivery of Antago-miR-483-5p Inhibits Osteoarthritis by Modulating Matrilin 3 and Tissue Inhibitor of Metalloproteinase 2." dans: Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 25, Issue 3, pp. 715-727, (2017) (PubMed).

Li, Xu, Xing, Qian, Chen, Gu, Guo, Lai, Zhao, Li, Wang, Wang, Deng: "A Conditional Knockout Mouse Model Reveals a Critical Role of PKD1 in Osteoblast Differentiation and Bone Development." dans: Scientific reports, Vol. 7, pp. 40505, (2017) (PubMed).

Wu, Wang, Ji, Ou, Xia, Zhang, Zhao: "C4orf7 modulates osteogenesis and adipogenesis of human periodontal ligament cells." dans: American journal of translational research, Vol. 9, Issue 12, pp. 5708-5718, (2017) (PubMed).

Détails sur RUNX2

Antigène: RUNX2 (Runt-Related Transcription Factor 2 (RUNX2))

Autre désignation: RUNX2

Sujet: This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.,RUNX2,AML3,CBF-alpha-1,CBFA1,CCD,CCD1,CLCD,OSF-2,OSF2,PEA2aA,PEBP2aA,Epigenetics & Nuclear Signaling,Transcription Factors,Cell Biology & Developmental Biology,Extracellular Matrix,Bone,Hippo Signaling Pathway,Stem Cells,Mesenchymal Stem Cells,Target gene,RUNX2

Poids moléculaire: 54 kDa/55 kDa/56 kDa

ID gène: 860

UniProt: Q13950