DDIT3 anticorps (C-Term)

N° du produit ABIN3020710

Cité dans 3 publications. Cet anticorps anti-DDIT3 Polyclonal Lapin (ABIN3020710) détecte spécifiquement DDIT3 dans WB et IF. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour DDIT3 anticorps (C-Term) (ABIN3020710)

Antigène: DDIT3 (DNA-Damage-Inducible Transcript 3 (DDIT3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DDIT3 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-DDIT3 anticorps

Épitope: C-Term

Séquence: GRTRKRKQSG HSPARAGKQR MKEKEQENER KVAQLAEENE RLKQEIERLT REVEATRRAL IDRMVNLHQA

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human DDIT3/CHOP (NP_004074.2).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze / thaw cycles

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Références pour anticorps anti-DDIT3 (ABIN3020710)

Zhang, Yan, Wang, Dai, Wang, Cai: "Autophagy May Protect Against Parenteral Nutrition-Associated Liver Disease by Suppressing Endoplasmic Reticulum Stress." dans: JPEN. Journal of parenteral and enteral nutrition, Vol. 43, Issue 1, pp. 96-106, (2019) (PubMed).

Anasa, Manickam, Talwar, Ravanan: "Identification of ASB7 as ER stress responsive gene through a genome wide in silico screening for genes with ERSE." dans: PLoS ONE, Vol. 13, Issue 4, pp. e0194310, (2018) (PubMed).

Knowlton, Fernández de Castro, Ashbrook, Gestaut, Zamora, Bauer, Forrest, Frydman, Risco, Dermody: "The TRiC chaperonin controls reovirus replication through outer-capsid folding." dans: Nature microbiology, Vol. 3, Issue 4, pp. 481-493, (2018) (PubMed).

Détails sur DDIT3

Antigène: DDIT3 (DNA-Damage-Inducible Transcript 3 (DDIT3))

Autre désignation: DDIT3

Sujet: This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified.,DDIT3,CEBPZ,CHOP,CHOP-10,CHOP10,GADD153,C/EBPzeta,DDIT3 / CHOP,Epigenetics & Nuclear Signaling,Transcription Factors,Signal Transduction,MAPK-P38 Signaling Pathway,Cell Biology & Developmental Biology,Autophagy,Protein folding,Endocrine & Metabolism,Endocrine and metabolic diseases,Diabetes,Metabolic disorders,Obesity,Stem Cells,Embryonic Stem Cells,DDIT3

Poids moléculaire: 19 kDa/21 kDa

ID gène: 1649

UniProt: P35638

Pathways: Regulation of Muscle Cell Differentiation, ER-Nucleus Signaling, Skeletal Muscle Fiber Development, Cell RedoxHomeostasis