FAS anticorps (AA 150-250)

N° du produit ABIN3020739

L’anticorps Lapin Polyclonal anti-FAS a été validé pour WB. Il convient pour détecter FAS dans des échantillons de Humain. Il y a 4+ publications disponibles.

Aperçu rapide pour FAS anticorps (AA 150-250) (ABIN3020739)

Antigène: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FAS est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-FAS anticorps

Épitope: AA 150-250

Séquence: EHGIIKECTL TSNTKCKEEG SRSNLGWLCL LLLPIPLIVW VKRKEVQKTC RKHRKENQGS HESPTLNPET VAINLSDVDL SKYITTIAGV MTLSQVKGFV R

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: A synthetic peptide corresponding to a sequence within amino acids 150-250 of human Fas (NP_000034.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze / thaw cycles

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Références pour anticorps anti-FAS (ABIN3020739)

Wang, Yan, Xiao, Zhou, Liu, Zeng, Liu, Li, Yuan, Wu, Yi, Razack, Wen: "Anti-obesity effect of a traditional Chinese dietary habit-blending lard with vegetable oil while cooking." dans: Scientific reports, Vol. 7, Issue 1, pp. 14689, (2017) (PubMed).

Chen, Gu, Jiang, Zhang: "Nuclear translocation of nuclear factor kappa B is regulated by G protein signaling pathway in arsenite-induced apoptosis in HBE cell line." dans: Environmental toxicology, (2015) (PubMed).

Gu, Chen, Jiang, Zhang: "Resveratrol Synergistically Triggers Apoptotic Cell Death with Arsenic Trioxide via Oxidative Stress in Human Lung Adenocarcinoma A549 Cells." dans: Biological trace element research, Vol. 163, Issue 1-2, pp. 112-23, (2015) (PubMed).

Chen, Jiang, Lai, Liu, Zhang: "Resveratrol protects against arsenic trioxide-induced oxidative damage through maintenance of glutathione homeostasis and inhibition of apoptotic progression." dans: Environmental and molecular mutagenesis, (2014) (PubMed).

Détails sur FAS

Antigène: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Autre désignation: FAS

Sujet: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.,ALPS1A,APO-1,APT1,CD95,FAS1,FASTM,TNFRSF6,FAS,Cell Biology & Developmental Biology,Apoptosis,Mitochondrial Control of Apoptosis,Inhibition of Apoptosis,Death Receptor Signaling Pathway,Immunology & Inflammation,CD markers,Cytokines,TNF,Cell Intrinsic Innate Immunity Signaling Pathway,Neuroscience,Neurodegenerative Diseases,FAS

Poids moléculaire: 9 kDa/11 kDa/14 kDa/16 kDa/24 kDa/35 kDa/37 kDa

ID gène: 355

UniProt: P25445

Pathways: Signalisation p53, Apoptose, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity