INPP5D anticorps (N-Term)

N° du produit ABIN302082

Cet anticorps anti-INPP5D Monoclonal Souris (Clone SHIP-02) (ABIN302082) détecte spécifiquement INPP5D dans WB, ICC et ICFC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour INPP5D anticorps (N-Term) (ABIN302082)

Antigène: INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp INPP5D est non-conjugé

Application: Western Blotting (WB), Immunocytochemistry (ICC), Intracellular Flow Cytometry (ICFC)

Clone: SHIP-02

Détail du produit anti-INPP5D anticorps

Épitope: N-Term

Fonction: Anti-SHIP1 Purified

Réactivité croisée (Details): Human, Other not determined

Attributs du produit: The antibody SHIP-02 reacts with SHIP-1, a phosphoinositide phosphatase largely confined to hematopoietic cells (intracellular antigen). Multiple forms of SHIP-1 have been reported with molecular weights of 110, 125, 130, 135 and 145 kDa.

Purification: Purified by protein-A affinity chromatography.

Pureté: > 95 % (by SDS-PAGE)

Immunogène: Peptide coresponding to a sequence within N-terminal domain of Human SHIP-1.

Isotype: IgG2a

Information d'application

Indications d'application: Flow cytometry: Intracellular staining, recommended dilution: 2-5 μg/mL, positive control: human blood leukocytes.
Western blotting: Positive control: RAMOS human cell line, reducing conditions.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Détails sur INPP5D

Antigène: INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))

Autre désignation: SHIP1

Sujet: Inositol polyphosphate-5-phosphatase D,SHIP-1 (SH2 domain containing inositol phosphatase-1) is a 5´inositol phosphatase that regulates cell responses in lymphocytes and myeloid cells by hydrolyzing the second messenger PI(3,4,5) trisphosphate. SHIP-1 is recruited upon engagement of both inhibitory and activatory receptors, such as FcgammaRIIB, Fcgamma RIII, FcepsilonRI or cytokine and growth factor receptors, and supresses PI3K-dependent signaling, down-regulates cell migration and invasion of transformed cells and phagocytosis. SHIP-1 also serves as a scaffold for the recruitment of other proteins to the plasma membrane.,IPP5PD, IP5PD, INPP5D

ID gène: 3635

UniProt: Q92835

Pathways: TCR Signaling, BCR Signaling, L'effet Warburg