Dynactin 1 anticorps (AA 945-1139)

N° du produit ABIN3022542

Cet anticorps Lapin Polyclonal détecte spécifiquement Dynactin 1 dans WB et IP. Il présente une réactivité envers Humain.

Aperçu rapide pour Dynactin 1 anticorps (AA 945-1139) (ABIN3022542)

Antigène: Dynactin 1 (DCTN1)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Dynactin 1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Détail du produit anti-Dynactin 1 anticorps

Épitope: AA 945-1139

Séquence: PGLVKDSPLL LQQISAMRLH ISQLQHENSI LKGAQMKASL ASLPPLHVAK LSHEGPGSEL PAGALYRKTS QLLETLNQLS THTHVVDITR TSPAAKSPSA QLMEQVAQLK SLSDTVEKLK DEVLKETVSQ RPGATVPTDF ATFPSSAFLR AKEEQQDDTV YMGKVTFSCA AGFGQRHRLV LTQEQLHQLH SRLIS

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 945-1139 of human DCTN1 (NP_001128513.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IP,1:50 - 1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze / thaw cycles

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur Dynactin 1

Antigène: Dynactin 1 (DCTN1)

Autre désignation: DCTN1

Sujet: This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA).,DCTN1,DAP-150,DP-150,P135,Signal Transduction,Cell Biology & Developmental Biology,Cell Cycle,Centrosome,Cytoskeleton,Motor Proteins,Neuroscience,Neurodegenerative Diseases,DCTN1

Poids moléculaire: 126 kDa/127 kDa/136 kDa/138 kDa/140 kDa/141 kDa

ID gène: 1639

UniProt: Q14203

Pathways: M Phase, ER-Nucleus Signaling