Presenilin 1 anticorps (AA 1-160)

N° du produit ABIN3023160

Détail du produit anti-Presenilin 1 anticorps

Antigène: Presenilin 1 (PSEN1)

Épitope: AA 1-160

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Presenilin 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Séquence: MTELPAPLSY FQNAQMSEDN HLSNTNDNRE RQEHNDRRSL GHPEPLSNGR PQGNSRQVVE QDEEEDEELT LKYGAKHVIM LFVPVTLCMV VVVATIKSVS FYTRKDGQLI YTPFTEDTET VGQRALHSIL NAAIMISVIV VMTILLVVLY KYRCYKVIHA

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human Presenilin 1 (NP_015557.2).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze / thaw cycles

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur Presenilin 1

Antigène: Presenilin 1 (PSEN1)

Autre désignation: PSEN1 (PSEN1 Produits)

Synonymes: anticorps pre1, anticorps psen, anticorps zfPS1, anticorps zf-PS1, anticorps ad3, anticorps fad, anticorps ps1, anticorps s182, anticorps X-PS-beta, anticorps X-PS-alpha, anticorps AD3, anticorps FAD, anticorps PS-1, anticorps PS1, anticorps S182, anticorps Ad3h, anticorps presenilin 1, anticorps presenilin 1 L homeolog, anticorps psen1, anticorps PSEN1, anticorps Psen1, anticorps psen1.L

Sujet: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1, PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.,AD3,FAD,PS-1,PS1,S182,Presenilin 1,PSEN1,Cancer,Signal Transduction,ErbB-HER Signaling Pathway,Cell Biology & Developmental Biology,Autophagy,Notch Signaling Pathway,ESC Pluripotency and Differentiation,Endocrine & Metabolism,Neuroscience,Neurodegenerative Diseases,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,Neurodegenerative Diseases Markers,PSEN1

Poids moléculaire: 21 kDa/42 kDa/46 kDa/48 kDa/52 kDa

ID gène: 5663

UniProt: P49768

Pathways: Signalisation Notch, EGFR Signaling Pathway, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport