Presenilin 1 anticorps (AA 1-160)

N° du produit ABIN7164263

Détail du produit anti-Presenilin 1 anticorps

Antigène: Presenilin 1 (PSEN1)

Épitope: AA 1-160

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Presenilin 1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Presenilin-1 protein (1-160AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur Presenilin 1

Antigène: Presenilin 1 (PSEN1)

Autre désignation: PSEN1 (PSEN1 Produits)

Synonymes: anticorps pre1, anticorps psen, anticorps zfPS1, anticorps zf-PS1, anticorps ad3, anticorps fad, anticorps ps1, anticorps s182, anticorps X-PS-beta, anticorps X-PS-alpha, anticorps AD3, anticorps FAD, anticorps PS-1, anticorps PS1, anticorps S182, anticorps Ad3h, anticorps presenilin 1, anticorps presenilin 1 L homeolog, anticorps psen1, anticorps PSEN1, anticorps Psen1, anticorps psen1.L

Sujet:

Background: Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.

Aliases: AD3 antibody, Ad3h antibody, FAD antibody, Homo Sapiens Clone CC44 Senilin 1 antibody, Presenilin-1 CTF12 antibody, Protein S182 antibody, PS 1 antibody, PS-1 antibody, PS1-CTF12 antibody, PSEN1 antibody, PSN1_HUMAN antibody, PSNL1 antibody, S182 antibody

UniProt: P49768

Pathways: Signalisation Notch, EGFR Signaling Pathway, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport