PDE9A anticorps

N° du produit ABIN302526

Détail du produit anti-PDE9A anticorps

Antigène: PDE9A (phosphodiesterase 9A (PDE9A))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PDE9A est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects Phosphodiesterase 9A (PDE9A) at internal domain.

Purification: Immunoaffinity chromatography

Immunogène: PDE9A antibody was raised against synthetic peptide from human PDE9A.

Information d'application

Indications d'application: Immunohistochemistry on paraffin sections (20 μg/mL). Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1xTBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.09 % sodium azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -70 °C for longer.

Détails sur PDE9A

Antigène: PDE9A (phosphodiesterase 9A (PDE9A))

Autre désignation: PDE9A (PDE9A Produits)

Synonymes: anticorps PDE9A, anticorps MGC116558, anticorps Pde9a, anticorps HSPDE9A2, anticorps PDE9A1, anticorps phosphodiesterase 9A, anticorps phosphodiesterase 9A S homeolog, anticorps high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, anticorps PDE9A, anticorps pde9a.S, anticorps Pde9a, anticorps LOC100549810, anticorps pde9a

Sujet: Phosphodiesterase 9A is a cGMP-specific phosphodiesterase. PDE9A activity is inhibited by zaprinast, but it is insensitive to rolipram, vinpocetine, SKF-94120, dipyridamole, and IBMX. More than 20 alternatively spliced variants have been reported (Rentero et al. 2003). PDE9A has been implicated in penile erectile dysfunction, as well as in functional disturbances in which intraneuronal signal transmission via second messengers are important in the pathophysiology (example, bipolar affective disorder). PDE9A is the only cGMP-specific PDE with significant expression in the forebrain, and as such is likely to function in NO-cGMP signaling.Synonyms: 5'-cyclic phosphodiesterase 9A, HSPDE9A2, High affinity cGMP-specific 3', Phosphodiesterase 9A, Phosphodiesterase PDE9A21

ID gène: 5152

NCBI Accession: NP_001001567

UniProt: O76083